The climate changes, which occurred during the last decades, put all living species in front of new challenges. Human biology is no exception to it, all tissues have to face new effects, with unpredictable consequences. Many cancers, mainly affecting the skin, but also many of the eye various structures diseases, have ultraviolet radiation as recognized causative agent. The aim of our work is to highlight the changes that can occur after exposure to ultraviolet radiations of soft tissues, including eye structures, by reviewing data from the scientific literature regarding the matter. Responsible for severe diseases, including cancer, ultraviolet negative effects on various soft tissues can be limited by better comprehension. Their knowledge can contribute to improving public health, by finding new preventive methods, which might represent the foundation of effective public health programs.