Na+-independent L-aspartate binding sites in chick brain

Neurochem Res. 1988 Sep;13(9):879-85. doi: 10.1007/BF00970757.

Abstract

1. One binding component with a Kd value of 200 x 10(-9) M and half-life of the ligand binding component of 30 min was found. 2. Chloride ions produced a significant increase of L-[3H]aspartate and L-[3H]glutamate binding. 3. L-Glutamate, L-ibotenate, L-quisqualate, and DL-homocysteic acid were potent inhibitors of L-[3H]aspartate binding. 4. In all brain regions major increases of binding were observed during the third week of the in ovo period of life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Binding, Competitive
  • Brain / drug effects
  • Brain / metabolism*
  • Chickens / metabolism*
  • Kinetics
  • Receptors, Amino Acid*
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism*
  • Sodium / metabolism*
  • Temperature

Substances

  • Receptors, Amino Acid
  • Receptors, Cell Surface
  • aspartic acid receptor
  • Sodium