Highly Pathogenic Avian Influenza Virus (H5N8) Clade 2.3.4.4 Infection in Migratory Birds, Egypt

Emerg Infect Dis. 2017 Jun;23(6):1048-1051. doi: 10.3201/eid2306.162056.

Abstract

We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly emerging viruses is warranted.

Keywords: Africa; Egypt; clade 2.3.4.4; highly pathogenic avian influenza; influenza; migratory birds; subtype H5N8; viruses; zoonoses.

MeSH terms

  • Amino Acid Sequence
  • Animal Migration / physiology*
  • Animals
  • Animals, Wild
  • Birds
  • Egypt / epidemiology
  • Gene Expression
  • Hemagglutinin Glycoproteins, Influenza Virus / chemistry
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics*
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Influenza A Virus, H5N8 Subtype / classification
  • Influenza A Virus, H5N8 Subtype / genetics*
  • Influenza A Virus, H5N8 Subtype / isolation & purification
  • Influenza A Virus, H5N8 Subtype / pathogenicity
  • Influenza in Birds / epidemiology*
  • Influenza in Birds / transmission
  • Influenza in Birds / virology
  • Models, Molecular
  • Mutation
  • Phylogeny
  • Protein Conformation, alpha-Helical
  • Protein Conformation, beta-Strand
  • Reassortant Viruses / classification
  • Reassortant Viruses / genetics*
  • Reassortant Viruses / isolation & purification
  • Reassortant Viruses / pathogenicity

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • hemagglutinin, avian influenza A virus