Evaluation of carotid intima-media thickness with vascular endothelial growth factor and malondialdehyde levels in patients with sarcoidosis

N S Samanci; S Poturoglu; C Samanci; D Alis; H O Emre; M Koldas; H K Ozcelik; T Durmus; F Kantarci; S Ozturk

doi:10.1016/j.diii.2017.04.004

Evaluation of carotid intima-media thickness with vascular endothelial growth factor and malondialdehyde levels in patients with sarcoidosis

Diagn Interv Imaging. 2017 Jul-Aug;98(7-8):557-561. doi: 10.1016/j.diii.2017.04.004. Epub 2017 May 12.

Authors

N S Samanci¹, S Poturoglu², C Samanci³, D Alis⁴, H O Emre⁵, M Koldas⁶, H K Ozcelik⁷, T Durmus⁸, F Kantarci⁹, S Ozturk¹⁰

Affiliations

¹ Haseki research and training hospital internal medicine, 34096 Haseki, Istanbul, Turkey. Electronic address: nilaysengulsamanci@gmail.com.
² Haseki research and training hospital internal medicine, 34096 Haseki, Istanbul, Turkey. Electronic address: sulepot@mynet.com.
³ Department of radiology, KMPasa, Cerrahpasa faculty of medicine, Istanbul university, 34098 Istanbul, Turkey. Electronic address: cesursamanci@gmail.com.
⁴ Department of radiology, KMPasa, Cerrahpasa faculty of medicine, Istanbul university, 34098 Istanbul, Turkey. Electronic address: denizalis@gmail.com.
⁵ Biochemistry department, Haseki research and training hospital, 34096 Haseki, Istanbul, Turkey. Electronic address: hmyozemre@gmail.com.
⁶ Biochemistry department, Haseki research and training hospital, 34096 Haseki, Istanbul, Turkey. Electronic address: macitkoldas@gmail.com.
⁷ Pulmonology department, Bezmialem university, 34093 Istanbul, Turkey. Electronic address: hkurtbay54@hotmail.com.
⁸ Haseki research and training hospital internal medicine, 34096 Haseki, Istanbul, Turkey. Electronic address: tulayonalandurmus@yahoo.com.
⁹ Department of radiology, KMPasa, Cerrahpasa faculty of medicine, Istanbul university, 34098 Istanbul, Turkey. Electronic address: fatihkan@yahoo.com.
¹⁰ Haseki research and training hospital internal medicine, 34096 Haseki, Istanbul, Turkey. Electronic address: savasozturkdr@yahoo.com.

PMID: 28506681
DOI: 10.1016/j.diii.2017.04.004

Abstract

Purpose: To assess the impact of sarcoidosis on endothelial function by measuring carotid intima-media thickness (CIMT) and serum levels of malondialdehyde and vascular endothelial growth factor (VEGF).

Materials and methods: We prospectively analyzed 41 patients with sarcoidosis (9 men, 32 women) with a mean age of 44.9±10.2 (SD) years and 34 healthy subjects (9 men, 24 women) with a mean age of 37.26±8.9 (SD) years who served as a control group. Sarcoidosis patients receiving steroids were included in Group 1 while those not under steroid treatment were included in Group 2. CIMT measurements were performed using B-mode ultrasound. Malondialdehyde and VEGF serum levels were obtained in all sarcoidosis patients and control subjects.

Results: Both right and left CIMT was significantly higher in Group 1 and Group 2 than in control subjects. Serum levels of malondialdehyde and VEGF in Group 1 and Group 2 were significantly higher than in healthy subjects. No differences in CIMT, malondialdehyde and VEGF were found between Group 1 and Group 2.

Conclusion: Sarcoidosis results in increased CIMT, VEGF and malondialdehyde serum levels. However, there was no difference in terms of CIMT, VEGF and malondialdehyde levels between sarcoidosis patients with or without steroid treatment, suggesting that new treatment strategies for sarcoidosis vascular involvement should consider this result.

Keywords: Carotid intima-media thickness; Duplex Doppler ultrasound; Malondialdehyde; Sarcoidosis; Vascular endothelial growth factor (VEGF).