Increase in the prescription rate of antidepressants after the Sewol Ferry disaster in Ansan, South Korea

J Affect Disord. 2017 Sep:219:31-36. doi: 10.1016/j.jad.2017.05.026. Epub 2017 May 10.

Abstract

Background: Previous pharmaco-epidemiological studies have reported increases in the prescription of psychotropic medications after a disaster, reflecting post-disaster changes in psychiatric conditions and mental health service utilization. We investigated changes in the prescription of psychotropic medications in the Danwon district of Ansan city (Ansan Danwon) compared to a control community before and after the Sewol Ferry disaster on April 16, 2014.

Methods: Data was collected from the Korean Health Insurance Review and Assessment Service database. We analyzed the prescription rates of psychotropic medications including antidepressants, anxiolytics, and sedatives/hypnotics, and investigated whether the time-series pattern of monthly prescriptions per 100,000 people was different in Ansan Danwon compared to that in Cheonan city after the Sewol Ferry disaster through difference-in-differences regression analysis.

Results: Ansan Danwon showed a significantly greater increase (5.6%) in the prescription rate of antidepressants compared to Cheonan city following the Sewol Ferry disaster. There were no significant differences in changes in the prescription rates of anxiolytics or sedatives/hypnotics. In the secondary analysis, a significantly greater increase in the prescription rate of antipsychotics was observed in Ansan Danwon compared to a control community after the disaster.

Limitations: We could not exclude the possibility that other events influenced changes in the prescription rates of psychotropic medications during the study period.

Conclusions: Pharmaco-epidemiological studies on psychotropic medication prescription after a disaster provide important information about population-level mental health. Our results suggest that the Sewol Ferry disaster exerted a harmful effect on the mental health status of the affected community.

Keywords: Antidepressant; Anxiolytics; Disaster; Mental health; Prescription; Sewol Ferry disaster.

MeSH terms

  • Adult
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / therapeutic use*
  • Antipsychotic Agents / therapeutic use
  • Disasters*
  • Drug Prescriptions / statistics & numerical data*
  • Drug Utilization / statistics & numerical data*
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Male
  • Mental Disorders / drug therapy*
  • Mental Disorders / psychology
  • Psychotropic Drugs / therapeutic use*
  • Republic of Korea
  • Stress Disorders, Post-Traumatic / drug therapy*
  • Stress Disorders, Post-Traumatic / psychology

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antipsychotic Agents
  • Hypnotics and Sedatives
  • Psychotropic Drugs