Climate change and variability are considered some of the biggest threats to human health in the 21st century. Extreme weather events such as floods and storms are examples of natural hazards resulting in highest number of disasters and with considerable mortality and morbidity among vulnerable communities. A coordinated, well-planned management of health interventions must be taken for timely action in the response, recovery, prevention and preparedness phases of disasters. Roles and responsibilities of international as well as national organizations and authorities are discussed.