Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β

Comp Immunol Microbiol Infect Dis. 2017 Apr:51:15-26. doi: 10.1016/j.cimid.2017.02.001. Epub 2017 Mar 12.

Abstract

Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-β) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-β during the wound healing process and immunity against CL to offer a new insight about wound healing in CL.

Keywords: Cutaneous leishmaniasis; IL-10; Leishmania; TGF-β; Wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Interleukin-10 / deficiency
  • Interleukin-10 / genetics
  • Interleukin-10 / immunology*
  • Leishmaniasis, Cutaneous / immunology*
  • Mice
  • Th17 Cells
  • Transforming Growth Factor beta / deficiency
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / immunology*
  • Wound Healing / immunology*

Substances

  • IL10 protein, human
  • IL10 protein, mouse
  • Transforming Growth Factor beta
  • Interleukin-10