Treatment using tadalafil for severe pre-eclampsia with fetal growth restriction

J Obstet Gynaecol Res. 2017 Jul;43(7):1205-1208. doi: 10.1111/jog.13335. Epub 2017 May 15.

Abstract

For severe pre-eclampsia (PE) with fetal growth restriction (FGR), the only effective treatment is early delivery of the placenta. Clinicians are often forced to end the pregnancy because of maternal indications. We report a case of severe PE with FGR in which the PE was temporarily improved and pregnancy successfully prolonged with tadalafil, a phosphodiesterase 5 inhibitor. A 35-year-old primigravid woman presented at 27 3/7 weeks of gestation with severe PE and FGR. After commencing tadalafil administration, biochemical and angiogenic markers improved. Thereafter, hypertension and proteinuria temporarily improved. Importantly, the pregnancy was prolonged by 14 days after the initiation of tadalafil administration. Tadalafil may be a novel treatment for severe PE with FGR to prolong pregnancy.

Keywords: fetal growth restriction; pre-eclampsia; tadalafil.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fetal Growth Retardation / drug therapy*
  • Humans
  • Phosphodiesterase 5 Inhibitors / administration & dosage
  • Phosphodiesterase 5 Inhibitors / pharmacology*
  • Pre-Eclampsia / drug therapy*
  • Pregnancy
  • Tadalafil / administration & dosage
  • Tadalafil / pharmacology*

Substances

  • Phosphodiesterase 5 Inhibitors
  • Tadalafil