The Shared Etiology of Attentional Control and Anxiety: An Adolescent Twin Study

J Res Adolesc. 2017 Mar;27(1):122-138. doi: 10.1111/jora.12260. Epub 2016 Apr 9.

Abstract

We investigated the etiology of attentional control (AC) and four different anxiety symptom types (generalized, obsessive-compulsive, separation, and social) in an adolescent sample of over 400 twin pairs. Genetic factors contributed to 55% of the variance in AC and between 43 and 58% of the variance in anxiety. Negative phenotypic associations between AC and anxiety indicated that lower attentional ability is related to increased risk for all 4 anxiety categories. Genetic correlations between AC and anxiety phenotypes ranged from -.36 to -.47, with evidence of nonshared environmental covariance between AC and generalized and separation anxiety. Results suggest that AC is a phenotypic and genetic risk factor for anxiety in early adolescence, with somewhat differing levels of risk depending on symptomatology.

Publication types

  • Research Support, N.I.H., Extramural
  • Twin Study

MeSH terms

  • Adolescent
  • Adolescent Behavior / psychology*
  • Adolescent Development
  • Anxiety / etiology
  • Anxiety / genetics
  • Anxiety / psychology*
  • Attention
  • Factor Analysis, Statistical
  • Female
  • Gene-Environment Interaction
  • Humans
  • Inheritance Patterns
  • Male
  • Obsessive-Compulsive Disorder / etiology
  • Obsessive-Compulsive Disorder / genetics
  • Obsessive-Compulsive Disorder / psychology*
  • Phenotype
  • Quantitative Trait, Heritable
  • Temperament
  • Twins / genetics
  • Twins / psychology*