Efficient synthesis of cyclic P-stereogenic phosphinamides from acyclic chiral precursors via radical oxidative intramolecular aryl C-H phosphinamidation

Yuan-Hui Chen; Xu-Long Qin; Fu-She Han

doi:10.1039/c7cc02263h

Efficient synthesis of cyclic P-stereogenic phosphinamides from acyclic chiral precursors via radical oxidative intramolecular aryl C-H phosphinamidation

Chem Commun (Camb). 2017 May 30;53(43):5826-5829. doi: 10.1039/c7cc02263h.

Authors

Yuan-Hui Chen¹, Xu-Long Qin, Fu-She Han

Affiliation

¹ Key Lab of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China. fshan@ciac.ac.cn.

PMID: 28497148
DOI: 10.1039/c7cc02263h

Abstract

We present a highly efficient method for the synthesis of cyclic P-stereogenic phosphinamides via the Ce^(IV)-promoted radical oxidative aryl C-H phosphinamidation of acyclic P-stereogenic phosphinamides. The new protocol provides a useful platform for the versatile synthesis of various potentially useful P-stereogenic compounds.