Objective To understand the health-related quality of life (HRQoL) and its influencing factors in Jilin province and compare two life quality measurement methods. Methods The data of 13 700 people aged above 15 years in Jilin province were extracted from the National Health Services Survey 2013. Self-rated health scores and EuroQol 5-dimension utility values were used to evaluate the HRQoL. Multivariable linear regression model was used to analyze the influencing factors. Results The self-rated health score was 81.26±15.73 in Jilin province,while utility values of health status were 0.959±0.124. The influencing factors of HRQoL included age,residency,education,income,type of health insurance,having non-communicable chronic disease and having disease in last two weeks. The age under 45,income,having non-communicable chronic disease,and having disease in last two weeks had stronger effect on self-rated health,whereas residency and type of health insurance had more effect on utility values of health status. Conclusion People in Jilin province have good quality of life. Both methods have their advantages and weakness. It is important to choose the right evaluation method depended on the objective of a specific study.