In silico modeling of structural and porosity properties of additive manufactured implants for regenerative medicine

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1:76:810-817. doi: 10.1016/j.msec.2017.03.105. Epub 2017 Mar 16.

Abstract

Additive manufacturing technologies are a promising technology towards patient-specific implants for applications in regenerative medicine. The Net-Shape-Nonwoven technology is used to manufacture structures from short fibers with interconnected pores and large functional surfaces that are predestined for cell adhesion and growth. The present study reports on a modeling approach with a particular focus on the specific structural properties. The overall porosities and mean pore-sizes of the digital models are simulated according to liquid-displacement porosity in a tool implemented in the modeling software. This allows adjusting the process parameters fiber length and fiber diameter to generate biomimetic structures with pore-sizes adapted to the requirements of the tissue that is to be replaced. Modeling the structural and porosity properties of scaffolds and implants leads to an efficient use of the processed biomaterials as the trial-and-error method is avoided.

Keywords: Additive manufacturing; Fiber-based; Implant; Modeling; Pore-size; Scaffold.

MeSH terms

  • Biocompatible Materials
  • Computer Simulation*
  • Porosity
  • Prostheses and Implants
  • Regenerative Medicine
  • Tissue Engineering
  • Tissue Scaffolds

Substances

  • Biocompatible Materials