Do Adipocytes Emerge from Mural Progenitors?

Lavanya Vishvanath; Jonathan Z Long; Bruce M Spiegelman; Rana K Gupta

doi:10.1016/j.stem.2017.03.013

Do Adipocytes Emerge from Mural Progenitors?

Cell Stem Cell. 2017 May 4;20(5):585-586. doi: 10.1016/j.stem.2017.03.013.

Authors

Lavanya Vishvanath¹, Jonathan Z Long², Bruce M Spiegelman², Rana K Gupta³

Affiliations

¹ Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
³ Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: rana.gupta@utsouthwestern.edu.

PMID: 28475882
DOI: 10.1016/j.stem.2017.03.013

Abstract

Gupta and colleagues highlight recent work, including their own, that suggested based on lineage tracing that mural cells are adipogenic, contrasting with the conclusions of a recent Cell Stem Cell paper.

Publication types

Letter
Comment

MeSH terms

Adipocytes / cytology*
Adipocytes / metabolism
Animals
Male
Mice
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / metabolism
Myocytes, Smooth Muscle / cytology
Myocytes, Smooth Muscle / metabolism
Myosin Heavy Chains / metabolism
Pericytes / cytology
Pericytes / metabolism
Receptor, Platelet-Derived Growth Factor beta / metabolism
Stem Cells / cytology*
Stem Cells / metabolism

Substances

myosin 11, mouse
Receptor, Platelet-Derived Growth Factor beta
Myosin Heavy Chains