Eyeing the Fountain of Youth

Magali Saint-Geniez; Mariana Aparecida B Rosales

doi:10.1016/j.stem.2017.04.007

Eyeing the Fountain of Youth

Cell Stem Cell. 2017 May 4;20(5):583-584. doi: 10.1016/j.stem.2017.04.007.

Authors

Magali Saint-Geniez¹, Mariana Aparecida B Rosales²

Affiliations

¹ Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: magali_saintgeniez@meei.harvard.edu.
² Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA.

PMID: 28475881
DOI: 10.1016/j.stem.2017.04.007

Abstract

Stem cell-based disease modeling is an emerging technology for the mechanistic study and therapeutic screening of complex ocular pathologies. In this issue of Cell Stem Cell, Saini et al. (2017) show that iPSC-derived RPE cells from age-related macular degeneration patients express increased levels of pro-inflammatory factors that can be normalized by the anti-aging drug nicotinamide.

Publication types

Comment

MeSH terms

Choroid / cytology
Choroid / metabolism
High-Temperature Requirement A Serine Peptidase 1 / metabolism
Humans
Lysosomes / drug effects
Lysosomes / metabolism
Macular Degeneration / drug therapy
Macular Degeneration / metabolism*
Niacinamide / pharmacology
Niacinamide / therapeutic use
Oxidative Stress / drug effects
Proteins / metabolism
Retinal Pigment Epithelium / drug effects
Retinal Pigment Epithelium / metabolism
Vision Disorders / metabolism
Vision Disorders / physiopathology

Substances

ARMS2 protein, human
Proteins
Niacinamide
High-Temperature Requirement A Serine Peptidase 1
HTRA1 protein, human