Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies

Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12721. Epub 2017 Jun 26.

Abstract

Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown. In the present series, we describe five cases of dengue in patients living in endemic areas, emphasizing the prolonged course of the disease and the occurrence of prolonged viremia.

Keywords: HSCT; dengue virus; hematological malignancies; immunocompromised patients; prolonged viremia.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aged
  • Child, Preschool
  • Dengue / diagnosis*
  • Dengue / virology
  • Dengue Virus / genetics
  • Dengue Virus / isolation & purification*
  • Female
  • Fever
  • Hematologic Neoplasms
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunocompromised Host
  • Male
  • Middle Aged
  • Thrombocytopenia
  • Viremia / diagnosis*
  • Viremia / virology