New Diterpenoids from Clerodendranthus spicatus

Ya-Mei Li; Bing Xiang; Xiao-Zheng Li; Yong-Ming Yan; Yong-Xian Cheng

doi:10.1007/s13659-017-0128-8

New Diterpenoids from Clerodendranthus spicatus

Nat Prod Bioprospect. 2017 Jun;7(3):263-267. doi: 10.1007/s13659-017-0128-8. Epub 2017 May 3.

Authors

Ya-Mei Li^{1

2}, Bing Xiang¹, Xiao-Zheng Li^{1

2}, Yong-Ming Yan³, Yong-Xian Cheng^{4

5}

Affiliations

¹ Yunnan University of Traditional Chinese Medicine, Kunming, 650504, People's Republic of China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. yanym@mail.kib.ac.cn.
⁴ Yunnan University of Traditional Chinese Medicine, Kunming, 650504, People's Republic of China. yxcheng@mail.kib.ac.cn.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. yxcheng@mail.kib.ac.cn.

Abstract

Two new diterpenoids, neoorthosiphonones B and C (1 and 2), and one known diterpenoid, were isolated from the aerial parts of Clerodendranthus spicatus. Their structures including absolute configurations were determined by comprehensive spectroscopic analyses and X-ray crystallographic methods. No compound was found to inhibit fibronectin production at the concentration of 20 μM.

Keywords: Clerodendranthus spicatus; Diterpenoid; Neoorthosiphonones B and C.