Physical activity, obesity and survival in diffuse large B-cell and follicular lymphoma cases

Br J Haematol. 2017 Aug;178(3):442-447. doi: 10.1111/bjh.14702. Epub 2017 May 3.

Abstract

There is limited information concerning the impact of physical activity and obesity on non-Hodgkin lymphoma (NHL) prognosis. We examined the associations between pre-diagnosis physical activity and body mass index (BMI) with survival in 238 diffuse large B-cell (DLBCL) and 175 follicular lymphoma cases, with follow-up from 2000 to 2015. The most physically active DLBCL cases had 41% lower risk of dying in the follow-up period than the least active [Hazard ratio (HR) = 0·59, 95% confidence interval (CI) = 0·36-0·96], while obese follicular lymphoma cases had a 2·5-fold risk of dying (HR = 2·52, 95% CI = 1·27-5·00) compared with cases with normal BMI. NHL-specific survival results were similar.

Keywords: body mass index; diffuse large B-cell lymphoma; follicular lymphoma; physical activity; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Body Mass Index
  • British Columbia / epidemiology
  • Case-Control Studies
  • Exercise / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Life Style
  • Lymphoma, Follicular / complications*
  • Lymphoma, Follicular / drug therapy
  • Lymphoma, Follicular / mortality
  • Lymphoma, Follicular / physiopathology
  • Lymphoma, Large B-Cell, Diffuse / complications*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / physiopathology
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / mortality
  • Obesity / physiopathology
  • Prognosis
  • Rituximab / therapeutic use

Substances

  • Antineoplastic Agents
  • Rituximab

Grants and funding