Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans

Clin Implant Dent Relat Res. 2017 Aug;19(4):608-615. doi: 10.1111/cid.12490. Epub 2017 May 2.

Abstract

Background: Several types of bone grafts are used in ridge preservation procedures.

Purpose: To compare the healing of allografts and xenografts applied for alveolar ridge preservation.

Materials and methods: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft. A collagen membrane was used to cover the grafts, flaps were sutured. At baseline and 6 months later, clinical measurements including vertical and horizontal bone dimensions were taken. Histomorphometric analysis was performed.

Results: Both groups showed shrinkage of bone dimensions. At mesial, center and distal sites, the vertical changes in dimension were -0.6, 0.5, and -0.1 mm for the allograft and -1.1, -0.4, and -0.9 mm for the xenograft. The horizontal changes in dimensions were -1.4 mm for the allograft and -2.6 mm for the xenograft. New bone and residual graft material were 25.5 ± 10.1% and 33.8 ± 9.4% at the allograft and 35.3 ± 16.8% and 22.2 ± 13.4% at the xenograft sites. None of the differences was statistically significant.

Conclusion: Both grafting materials are suitable for the preservation of the alveolar ridge.

Keywords: allograft; alveolar ridge reconstruction; bone grafting; tooth extraction; xenograft.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Allografts / pathology
  • Alveolar Process / pathology
  • Alveolar Process / surgery
  • Alveolar Ridge Augmentation / methods*
  • Animals
  • Bone Transplantation / methods*
  • Cattle
  • Female
  • Heterografts / pathology
  • Humans
  • Male