Cu2+ Biological Imaging Probes Based on Different Sensing Mechanisms

Curr Med Chem. 2019;26(21):3958-4002. doi: 10.2174/0929867324666170428110724.

Abstract

In recent years, fluorescent probes have recently attracted attention from researchers. As a vital trace metal element, Cu2+ has an important role in the human body and environment. Therefore, the development and design of Cu2+ small-molecular fluorescent probes has been an active research area. This review focuses on the developments in the area of small-molecular fluorescent probes for Cu2+ in biological applications according to different sensing mechanisms including charge transfer (CT), electron transfer, energy transfer, excited-state intramolecular proton transfer (ESIPT).

Keywords: Biological applications; Cu2+ small-molecular fluorescent probes; Detection; Metal ions; Sensing mechanisms; charge transfer (CT)..

Publication types

  • Review

MeSH terms

  • Copper / analysis*
  • Copper / metabolism*
  • Electron Transport
  • Energy Transfer
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / metabolism
  • Humans
  • Optical Imaging / methods*
  • Protons
  • Small Molecule Libraries / analysis*
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry

Substances

  • Fluorescent Dyes
  • Protons
  • Small Molecule Libraries
  • Copper