Abstract
Background:
Nonalcoholic fatty liver disease (NAFLD), is currently a worldwide health problem. None of the existing treatment medications had got a satisfactory effect. Hua Tan Qu Shi (HTQS) decoction is a Chinese herbal formula, which has been used clinically to treat NAFLD for years. However, the underlying mechanisms are still unclear.
Methods:
High-fat diet (HFD) induced non-alcoholic fatty liver disease rats treated with or without HTQS decoction by gavage for 10 weeks and examined by serology, 24-h albuminuria, histology, immunohistochemistry, and molecular analyses.
Copyright © 2017 Elsevier Masson SAS. All rights reserved.
MeSH terms
-
Alanine Transaminase / blood
-
Alkaline Phosphatase / blood
-
Animals
-
Aspartate Aminotransferases / blood
-
Body Weight / drug effects
-
Caspase 3 / metabolism
-
Diet, High-Fat
-
Drugs, Chinese Herbal / pharmacology
-
Drugs, Chinese Herbal / therapeutic use*
-
Lipids / blood
-
Liver / drug effects
-
Liver / injuries*
-
Liver / pathology
-
Male
-
Non-alcoholic Fatty Liver Disease / blood
-
Non-alcoholic Fatty Liver Disease / drug therapy*
-
Non-alcoholic Fatty Liver Disease / enzymology
-
Non-alcoholic Fatty Liver Disease / pathology
-
Organ Size / drug effects
-
Protective Agents / pharmacology
-
Protective Agents / therapeutic use*
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
Rats, Wistar
Substances
-
Drugs, Chinese Herbal
-
Lipids
-
Protective Agents
-
RNA, Messenger
-
Aspartate Aminotransferases
-
Alanine Transaminase
-
Alkaline Phosphatase
-
Caspase 3