Protective effect of Hua Tan Qu Shi decoction against liver injury in rats with nonalcoholic fatty liver disease

Biomed Pharmacother. 2017 Jul:91:181-190. doi: 10.1016/j.biopha.2017.04.099. Epub 2017 Apr 28.

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD), is currently a worldwide health problem. None of the existing treatment medications had got a satisfactory effect. Hua Tan Qu Shi (HTQS) decoction is a Chinese herbal formula, which has been used clinically to treat NAFLD for years. However, the underlying mechanisms are still unclear.

Methods: High-fat diet (HFD) induced non-alcoholic fatty liver disease rats treated with or without HTQS decoction by gavage for 10 weeks and examined by serology, 24-h albuminuria, histology, immunohistochemistry, and molecular analyses.

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Body Weight / drug effects
  • Caspase 3 / metabolism
  • Diet, High-Fat
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Lipids / blood
  • Liver / drug effects
  • Liver / injuries*
  • Liver / pathology
  • Male
  • Non-alcoholic Fatty Liver Disease / blood
  • Non-alcoholic Fatty Liver Disease / drug therapy*
  • Non-alcoholic Fatty Liver Disease / enzymology
  • Non-alcoholic Fatty Liver Disease / pathology
  • Organ Size / drug effects
  • Protective Agents / pharmacology
  • Protective Agents / therapeutic use*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats, Wistar

Substances

  • Drugs, Chinese Herbal
  • Lipids
  • Protective Agents
  • RNA, Messenger
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Caspase 3