A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression

Susan Hall; Ben Desbrow; Shailendra Anoopkumar-Dukie; Andrew K Davey; Devinder Arora; Catherine McDermott; Matthew M Schubert; Anthony V Perkins; Milton J Kiefel; Gary D Grant

doi:10.1016/j.foodres.2015.07.027

A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression

Food Res Int. 2015 Oct;76(Pt 3):626-636. doi: 10.1016/j.foodres.2015.07.027. Epub 2015 Aug 4.

Affiliations

¹ Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Pharmacy, Griffith University, Queensland, Australia.
² Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Allied Health Sciences, Griffith University, Queensland, Australia.
³ Department of Biomedical Science, Bond University, Queensland, Australia.
⁴ Center for Physical Activity and Weight Management, University of Kansas Medical Center, KS, USA.
⁵ Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Medical Science, Griffith University, Queensland, Australia.
⁶ Institute for Glycomics, Griffith University, Queensland 4222, Australia; School of Natural Sciences, Griffith University, Nathan Campus, Queensland, Australia.
⁷ Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Pharmacy, Griffith University, Queensland, Australia. Electronic address: g.grant@griffith.edu.au.

PMID: 28455046
DOI: 10.1016/j.foodres.2015.07.027

Abstract

Coffee is a widely consumed beverage containing numerous biologically active constituents predominantly belonging to the polyphenol and alkaloid classes. It has been established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and retrospective cohort studies have assessed the effects of coffee consumption on the relative risk of developing major depressive disorder in humans. These studies have identified an inverse relationship between the consumption of caffeinated coffee and the risk of developing depression. Caffeine, chlorogenic acid, ferulic acid and caffeic acid, all important constituents of coffee, have been shown to possess biological activities that highlight a possible mechanistic link to the pathology of depression. This review aims to assess the evidence from the biological evaluation of these constituents of coffee on markers of inflammation associated with depression in in vitro and in vivo models of inflammation, neuroinflammation and depression. The ability of bioactive coffee constituents to modulate the parameters of neuroinflammation has been shown with caffeine having strong antioxidant properties in vitro, chlorogenic acid and caffeic acid having strong anti-inflammatory and antioxidant properties in vitro and ferulic acid having activities in in vivo animal models of depression.

Keywords: Caffeic acid; Caffeine; Chlorogenic acid; Coffee; Ferulic acid; Inflammation; Oxidative stress.

Publication types

Review