New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent

Antonella Guerriero; Werner Oberhauser; Tina Riedel; Maurizio Peruzzini; Paul J Dyson; Luca Gonsalvi

doi:10.1021/acs.inorgchem.7b00915

New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent

Inorg Chem. 2017 May 15;56(10):5514-5518. doi: 10.1021/acs.inorgchem.7b00915. Epub 2017 Apr 26.

Authors

Antonella Guerriero¹, Werner Oberhauser¹, Tina Riedel², Maurizio Peruzzini¹, Paul J Dyson², Luca Gonsalvi¹

Affiliations

¹ Istituto di Chimica dei Composti Organometallici, Consiglio Nazionale delle Ricerche , Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy.
² Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale Lausanne , CH-1015 Lausanne, Switzerland.

PMID: 28443659
DOI: 10.1021/acs.inorgchem.7b00915

Abstract

Ruthenium(II) arene complexes of 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) were obtained. Cytotoxicity studies against cancer cell lines reveal higher activity than the corresponding PTA analogues and, in comparison to the effects on noncancerous cells, the complexes are endowed with a reasonable degree of cancer cell selectivity.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HEK293 Cells
Humans
Ligands
Molecular Structure
Ruthenium / chemistry
Ruthenium / pharmacology*
Solubility
Structure-Activity Relationship
Water / chemistry

Substances

Antineoplastic Agents
Coordination Complexes
Ligands
Water
Ruthenium