Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-κB and MAPKs in IL-1β-stimulated human OA chondrocytes

Nazir M Khan; Abdul Haseeb; Mohammad Y Ansari; Pratap Devarapalli; Sara Haynie; Tariq M Haqqi

doi:10.1016/j.dib.2017.03.054

Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-κB and MAPKs in IL-1β-stimulated human OA chondrocytes

Data Brief. 2017 Apr 9:12:150-155. doi: 10.1016/j.dib.2017.03.054. eCollection 2017 Jun.

Authors

Nazir M Khan¹, Abdul Haseeb¹, Mohammad Y Ansari¹, Pratap Devarapalli¹, Sara Haynie¹, Tariq M Haqqi¹

Affiliation

¹ Department of Anatomy & Neurobiology, Northeast Ohio Medical University, 4209 St Rt 44, Rootstown, OH 44272, USA.

Abstract

This article contains data related to the article "Wogonin, a plant derived small molecule exerts potent anti-inflammatory and chondroprotective effects through activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes" (Khan et al. 2017) [1]. The data are related to effects of Wogonin on the viability and IL-1β-stimulated activation of NF-κB and ERK1/2, JNK1/2 and p38 MAPKs in human OA chondrocytes. Gene expression data representing the chondrogenic phenotype and the efficiency of Nrf2 knockdown in monolayer culture of human OA chondrocytes were shown. Moreover, mass spectrometric calibration curve of Wogonin used to quantify the intracellular uptake were also presented. The data are presented in the form of figures and significance of these has been given in the research article (Khan et al. 2017) [1].

Keywords: MAPK; Mass-spectrometry; NF-κB; Nrf2; Osteoarthritis; Wogonin.