Gut Microbiota: Small Molecules Modulate Host Cellular Functions

Jacob M Luber; Aleksandar D Kostic

doi:10.1016/j.cub.2017.03.026

Gut Microbiota: Small Molecules Modulate Host Cellular Functions

Curr Biol. 2017 Apr 24;27(8):R307-R310. doi: 10.1016/j.cub.2017.03.026.

Authors

Jacob M Luber¹, Aleksandar D Kostic²

Affiliations

¹ Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jluber@g.harvard.edu.
² Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aleksandar.kostic@joslin.harvard.edu.

PMID: 28441565
DOI: 10.1016/j.cub.2017.03.026

Abstract

The human gut metagenome was recently discovered to encode vast collections of biosynthetic gene clusters with diverse chemical potential, almost none of which are yet functionally validated. Recent work elucidates common microbiome-derived biosynthetic gene clusters encoding peptide aldehydes that inhibit human proteases.

Publication types

Comment

MeSH terms

Gastrointestinal Microbiome*
Humans
Metagenome
Microbiota*
Multigene Family
Peptide Hydrolases

Substances

Peptide Hydrolases