Diabetes mellitus and acquired haemophilia: new association?

BMJ Case Rep. 2017 Apr 24:2017:bcr2017219807. doi: 10.1136/bcr-2017-219807.

Abstract

Diabetes mellitus encompasses a group of highly prevalent carbohydrate metabolic disorders with an increasing incidence. Some subtypes are thought to be associated with other immune-mediated diseases. Acquired haemophilia on the other hand is a quite rare autoimmune disease that is thought to be secondary to the emergence of inhibiting anticoagulation factor VIII antibodies (inhibitors) in patients with previously normal haemostatic function. More recently, numerous different diseases have been associated with acquired haemophilia namely immune-mediated diseases, drugs and solid and haematologic neoplasms. The authors report on a case of a patient with new onset acquired haemophilia arising in the setting of diabetic ketoacidosis.

Keywords: Diabetes; Haematology (incl blood transfusion).

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Diabetic Ketoacidosis / complications*
  • Diabetic Ketoacidosis / drug therapy
  • Female
  • Hemophilia A / etiology*
  • Hemophilia A / therapy
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Hypoglycemic Agents
  • Insulin

Supplementary concepts

  • Factor 8 deficiency, acquired