Molecular dynamics simulations reveal the influence of dextran sulfate in nanoparticle formation with calcium alginate to encapsulate insulin

J Biomol Struct Dyn. 2018 Apr;36(5):1255-1260. doi: 10.1080/07391102.2017.1318305. Epub 2017 Apr 24.

Authors

Daniela Nadvorny¹, José Lamartine Soares-Sobrinho¹, Monica F de La Roca Soares¹, Antônio José Ribeiro², Francisco Veiga², Gustavo M Seabra³

Affiliations

¹ a Núcleo de Controle de Qualidade de Medicamentos e Correlatos, Departamento de Ciências Farmacêuticas , Universidade Federal de Pernambuco , Recife , Brazil.
² b Faculdade de Farmácia , Universidade de Coimbra , Coimbra , Portugal.
³ c Departamento de Química Fundamental , Universidade Federal de Pernambuco , Recife , Brazil.

PMID: 28438077
DOI: 10.1080/07391102.2017.1318305

No abstract available

Keywords: calcium alginate; dextran sulfate; drug delivery; insulin; molecular dynamics.

MeSH terms

Alginates / chemistry*
Dextran Sulfate / chemistry*
Drug Carriers / chemistry
Drug Compounding
Drug Delivery Systems
Hydrogen Bonding
Insulin / administration & dosage
Insulin / chemistry*
Molecular Conformation
Molecular Dynamics Simulation*
Molecular Structure
Nanoparticles / chemistry*
Spectrum Analysis

Substances

Alginates
Drug Carriers
Insulin
Dextran Sulfate