Refine penetrance estimates in the main pathogenic variants of transthyretin hereditary (familial) amyloid polyneuropathy (TTR-FAP) using a new non-parametric approach (NPSE)

Affiliations

• ¹ a Department of Neurology , Henri Mondor University Hospital, AP-HP , Créteil , France.
• ² b Amyloid Network, Amyloid RESEARCH INSTITUTE , Créteil , France.
• ³ c Paris-Est Créteil University , Créteil , France.
• ⁴ d Laboratory MAP5 UMR CNRS 8145 , Paris Descartes University , France.
• ⁵ e UMR-S 669 - Inserm, U669, University Paris-Sud , Villejuif , France.
• ⁶ f Department of Genetics , Henri Mondor University Hospital, AP-HP , Créteil , France.
• ⁷ g Department of Cardiology , Henri Mondor University Hospital, AP-HP , Créteil , France.
• ⁸ h Inserm U.955, Institut Mondor de Recherche Biomédicale , Créteil , France , and.
• ⁹ i Institute of Mathematics, National Center for French Research, Laboratory of Probability, University Pierre et Marie Curie, Sorbonne University , Paris , France.