Paraneoplastic jaundice and prostate cancer

BMJ Case Rep. 2017 Apr 22:2017:bcr2016218001. doi: 10.1136/bcr-2016-218001.

Abstract

Cholestasis has numerous causes. We present the case of a 78-year-old man with a common diagnosis in this age group and gender but with an unusual presentation. There are only 11 articles published of patients with jaundice due to a paraneoplastic syndrome associated with prostate cancer. Interleukin 6 and other proinflammatory cytokines appear to contribute to the pathophysiology of this syndrome. Our patient remains symptom free 4 months after treatment initiation.

Keywords: Oncology; Prostate; Prostate Cancer; Urological cancer; Urology.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anilides / administration & dosage*
  • Anilides / therapeutic use
  • Humans
  • Jaundice / etiology*
  • Male
  • Neoplasm Metastasis
  • Nitriles / administration & dosage*
  • Nitriles / therapeutic use
  • Paraneoplastic Syndromes / diagnosis*
  • Paraneoplastic Syndromes / drug therapy
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / drug therapy
  • Tosyl Compounds / administration & dosage*
  • Tosyl Compounds / therapeutic use
  • Treatment Outcome

Substances

  • Anilides
  • Nitriles
  • Tosyl Compounds
  • bicalutamide