Tolterodine tartrate belongs to the family of muscarinic receptor antagonists and is indicated for the treatment of overactive urinary bladder syndrome. This chapter provides an overview of physical, analytical, and ADME profiles; highlights methods of chemical synthesis; and discusses stability of tolterodine as a free base and/or its l-tartrate salt in solution and in the solid state. The information presented in this chapter is based on the peer-reviewed literature, compendial reports (USP, EP), and authors' data. Patent literature is included only in a few instances.
Keywords: ADME profile; Analytical profile; Gauge-including projector augmented wave; Methods of chemical synthesis; Muscarinic receptor antagonists; Solid-state NMR; Stability; Stereoselective synthesis; Tolterodine and Tolterodine tartrate.
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