Recent aspects of uranium toxicology in medical geology

Environ Res. 2017 Jul:156:526-533. doi: 10.1016/j.envres.2017.04.010. Epub 2017 Apr 26.

Abstract

Uranium (U) is a chemo-toxic, radiotoxic and even a carcinogenic element. Due to its radioactivity, the effects of U on humans health have been extensively investigated. Prolonged U exposure may cause kidney disease and cancer. The geological distribution of U radionuclides is still a great concern for human health. Uranium in groundwater, frequently used as drinking water, and general environmental pollution with U raise concerns about the potential public health problem in several areas of Asia. The particular paleo-geological hallmark of India and other Southern Asiatic regions enhances the risk of U pollution in rural and urban communities. This paper highlights different health and environmental aspects of U as well as uptake and intake. It discusses levels of U in soil and water and the related health issues. Also described are different issues of U pollution, such as U and fertilizers, occupational exposure in miners, use and hazards of U in weapons (depleted U), U and plutonium as catalysts in the reaction between DNA and H2O2, and recycling of U from groundwater to surface soils in irrigation. For use in medical geology and U research, large databases and data warehouses are currently available in Europe and the United States.

Keywords: Depleted uranium; Drinking water; Environment; Health; Mining; Uranium.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA / metabolism
  • Fertilizers
  • Geology
  • Humans
  • Hydrogen Peroxide / metabolism
  • Neoplasms / epidemiology
  • Neoplasms / etiology
  • Radiation Monitoring
  • Soil Pollutants, Radioactive / analysis
  • Soil Pollutants, Radioactive / toxicity*
  • Uranium / analysis
  • Uranium / toxicity*
  • Water Pollutants, Radioactive / analysis
  • Water Pollutants, Radioactive / toxicity*

Substances

  • Fertilizers
  • Soil Pollutants, Radioactive
  • Water Pollutants, Radioactive
  • Uranium
  • DNA
  • Hydrogen Peroxide