Non-Pincer-Type Manganese Complexes as Efficient Catalysts for the Hydrogenation of Esters

Robbert van Putten; Evgeny A Uslamin; Marcel Garbe; Chong Liu; Angela Gonzalez-de-Castro; Martin Lutz; Kathrin Junge; Emiel J M Hensen; Matthias Beller; Laurent Lefort; Evgeny A Pidko

doi:10.1002/anie.201701365

Non-Pincer-Type Manganese Complexes as Efficient Catalysts for the Hydrogenation of Esters

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7531-7534. doi: 10.1002/anie.201701365. Epub 2017 Apr 21.

Authors

Affiliations

¹ Inorganic Materials Chemistry Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
² Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Strasse 29a, 18059, Rostock, Germany.
³ DSM Ahead R&D B.V. Innovative Synthesis, P.O. Box 18, 6160 MD, Geleen, The Netherlands.
⁴ Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
⁵ ITMO University, Kronverskskiy pr., 49, 197101, St. Petersburg, Russia.

Abstract

Catalytic hydrogenation of carboxylic acid esters is essential for the green production of pharmaceuticals, fragrances, and fine chemicals. Herein, we report the efficient hydrogenation of esters with manganese catalysts based on simple bidentate aminophosphine ligands. Monoligated Mn PN complexes are particularly active for the conversion of esters into the corresponding alcohols at Mn concentrations as low as 0.2 mol % in the presence of sub-stoichiometric amounts of KO^t Bu base.

Keywords: alcohols; esters; homogeneous catalysis; hydrogenation; manganese.

Publication types

Research Support, Non-U.S. Gov't