Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver

S P Syatkin; A A Kirichuk; A T Soldatenkov; S V Kutyakov; E V Neborak; N A Shevkun; O M Kuznetsova; A S Skorik; A A Terent'ev

doi:10.1007/s10517-017-3717-y

Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver

Bull Exp Biol Med. 2017 Apr;162(6):801-807. doi: 10.1007/s10517-017-3717-y. Epub 2017 Apr 21.

Authors

S P Syatkin¹, A A Kirichuk², A T Soldatenkov², S V Kutyakov², E V Neborak², N A Shevkun², O M Kuznetsova², A S Skorik², A A Terent'ev³

Affiliations

¹ Peoples' Friendship University of Russia, Moscow, Russia. syata@mail.ru.
² Peoples' Friendship University of Russia, Moscow, Russia.
³ N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 28429226
DOI: 10.1007/s10517-017-3717-y

Abstract

We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.

Keywords: diamine oxidase; polyamine oxidase; polyamines; spermidine; spermine.

MeSH terms

Amine Oxidase (Copper-Containing) / chemistry*
Aniline Compounds / chemical synthesis
Aniline Compounds / pharmacology*
Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology*
Boron Compounds / chemical synthesis
Boron Compounds / pharmacology*
Carcinogens / chemical synthesis
Carcinogens / pharmacology*
Cell-Free System / chemistry
Cell-Free System / drug effects
Cell-Free System / metabolism
Enzyme Assays
Kinetics
Liver / chemistry
Liver / metabolism
Liver Regeneration
Male
Oxidation-Reduction
Oxidoreductases Acting on CH-NH Group Donors / chemistry*
Polyamine Oxidase
Putrescine / chemistry
Pyridines / chemical synthesis
Pyridines / pharmacology*
Rats
Spermidine / chemistry
Spermine / chemistry
Structure-Activity Relationship

Substances

Aniline Compounds
Antineoplastic Agents
Boron Compounds
Carcinogens
Pyridines
Spermine
Amine Oxidase (Copper-Containing)
Oxidoreductases Acting on CH-NH Group Donors
Spermidine
Putrescine