Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

A V Arutyunyan; I V Zaloznyaya; G O Kerkeshko; Yu P Milyutina; A V Korenevskii

doi:10.1007/s10517-017-3701-6

Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

Bull Exp Biol Med. 2017 Apr;162(6):738-740. doi: 10.1007/s10517-017-3701-6. Epub 2017 Apr 20.

Authors

A V Arutyunyan¹, I V Zaloznyaya², G O Kerkeshko², Yu P Milyutina², A V Korenevskii²

Affiliations

¹ D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia. alexarutjunyan@gmail.com.
² D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia.

PMID: 28429210
DOI: 10.1007/s10517-017-3701-6

Abstract

Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.

Keywords: catecholamines; gonadotropin-releasing hormone; hypothalamus; prenatal hyperhomocysteinemia.

MeSH terms

Animals
Antioxidants / pharmacology*
Arcuate Nucleus of Hypothalamus / drug effects
Arcuate Nucleus of Hypothalamus / metabolism
Arcuate Nucleus of Hypothalamus / physiopathology
Catecholamines / metabolism
Estrous Cycle / drug effects*
Female
Gonadotropin-Releasing Hormone / metabolism
Hyperhomocysteinemia / chemically induced
Hyperhomocysteinemia / metabolism
Hyperhomocysteinemia / physiopathology
Hyperhomocysteinemia / prevention & control*
Luteinizing Hormone / metabolism
Median Eminence / drug effects
Median Eminence / metabolism
Median Eminence / physiopathology
Melatonin / pharmacology*
Methionine / adverse effects
Methionine / metabolism
Neuroprotective Agents / pharmacology*
Norepinephrine / metabolism
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced
Prenatal Exposure Delayed Effects / metabolism
Prenatal Exposure Delayed Effects / physiopathology
Prenatal Exposure Delayed Effects / prevention & control*
Preoptic Area / drug effects
Preoptic Area / metabolism
Preoptic Area / physiopathology
Progesterone / metabolism
Rats
Rats, Wistar

Substances

Antioxidants
Catecholamines
Neuroprotective Agents
Gonadotropin-Releasing Hormone
Progesterone
Luteinizing Hormone
Methionine
Melatonin
Norepinephrine