Three hexametal-organic cages [(N^N)6Pd6L2]6+ with syn, syn, syn conformation were synthesized via the coordination of tris(4-(1H-pyrazol-3-yl)phenyl)amine ligands and [(N^N)2Pd2(NO3)2](NO3)2 dimetallic corners (N^N = 2,2'-bipyridine for 1; 4,4'-dimethylbipyridine for 2; 1,10-phenanthroline for 3). These hexametal-organic cages exhibit anion sensing toward HSO3- in aqueous solution via fluorescent titration and NMR spectroscopy studies.