Clinical chemoproteomics-Opportunities and obstacles

Sci Transl Med. 2017 Apr 19;9(386):eaaf7951. doi: 10.1126/scitranslmed.aaf7951.

Abstract

Chemoproteomics is the large-scale study of proteins using chemical methods. Although chemoproteomic techniques are becoming commonplace in preclinical research, few examples have found clinical utility. We explore the prospects for advancing chemoproteomics into the clinical setting to understand drug-target interactions and to identify new therapeutically relevant targets.

Publication types

  • Review

MeSH terms

  • Drug Design
  • Proteins / chemistry
  • Proteins / metabolism
  • Proteomics / methods*

Substances

  • Proteins