Nanosystem trends in drug delivery using quality-by-design concept

Jing Li; Yanjiang Qiao; Zhisheng Wu

doi:10.1016/j.jconrel.2017.04.019

Nanosystem trends in drug delivery using quality-by-design concept

J Control Release. 2017 Jun 28:256:9-18. doi: 10.1016/j.jconrel.2017.04.019. Epub 2017 Apr 13.

Authors

Jing Li¹, Yanjiang Qiao¹, Zhisheng Wu²

Affiliations

¹ Beijing University of Chinese Medicine, 100102, China; Pharmaceutical Engineering and New Drug Development of TCM of Ministry of Education, 100102, China; Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing 100102, China.
² Beijing University of Chinese Medicine, 100102, China; Pharmaceutical Engineering and New Drug Development of TCM of Ministry of Education, 100102, China; Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing 100102, China. Electronic address: wzs@bucm.edu.cn.

PMID: 28414149
DOI: 10.1016/j.jconrel.2017.04.019

Abstract

Quality by design (QbD) has become an inevitable trend because of its benefits for product quality and process understanding. Trials have been conducted using QbD in nanosystems' optimization. This paper reviews the application of QbD for processing nanosystems and summarizes the application procedure. It provides prospective guidelines for future investigations that apply QbD to nanosystem manufacturing processes. Employing the QbD concept in this way is a novel area in nanosystem quality.

Keywords: Design of experiment; Nano-systems; Process analytical technology; Quality by design.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Design
Nanotechnology*
Technology, Pharmaceutical*