Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus

Michael C Rahe; Michael P Murtaugh

doi:10.1016/j.vetimm.2017.02.002

Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus

Vet Immunol Immunopathol. 2017 Apr:186:15-18. doi: 10.1016/j.vetimm.2017.02.002. Epub 2017 Feb 20.

Authors

Michael C Rahe¹, Michael P Murtaugh²

Affiliations

¹ Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN, 55108 USA. Electronic address: rahex008@umn.edu.
² Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN, 55108 USA.

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to afflict swine nearly 30 years after it was first discovered as the causative agent of "mystery swine disease". Immunological tools of vaccination and exposure to virulent viruses have not succeeded in achieving control and prevention of PRRSV. Humoral immunity, mediated by antibodies, is a hallmark of anti-viral immunity, but little is known about the effector mechanisms of humoral immunity against PRRSV. It is essential to understand the immunological significance of antibody functions, including recently described broadly neutralizing antibodies and potential non-neutralizing activities, in the immune response to PRRSV. Here, we review recent research from PRRSV and other host-pathogen interactions to inform novel routes of exploration into PRRSV humoral immunity which may be important for identifying the immunological correlates of protection against PRRSV infection.

Keywords: Antibody function; B cell; Humoral immunity; Neutralizing antibody; PRRSV.

Publication types

Review

MeSH terms

Animals
Immunity, Humoral*
Porcine respiratory and reproductive syndrome virus / immunology*
Swine

Grants and funding

T32 OD010993/OD/NIH HHS/United States