Enzyme-induced dual-network ε-poly-l-lysine-based hydrogels with robust self-healing and antibacterial performance

Chem Commun (Camb). 2017 Apr 27;53(35):4803-4806. doi: 10.1039/c6cc09326d.

Abstract

An enzyme-induced strategy is reported to construct novel self-mending hydrogels based on ε-poly-l-lysine with both excellent self-healing properties (95%) and antibacterial capacity. Most importantly, the hydrogels are able to accelerate wound healing efficiently, which shows great potential in myriad biomedical fields, such as wound repair, artificial skin, and tissue engineering.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Escherichia coli / drug effects*
  • Fibroblasts / drug effects
  • Humans
  • Hydrogels / chemistry
  • Hydrogels / metabolism
  • Hydrogels / pharmacology*
  • Microbial Sensitivity Tests
  • Monoamine Oxidase / blood
  • Monoamine Oxidase / metabolism*
  • Polylysine / chemistry
  • Polylysine / metabolism
  • Polylysine / pharmacology*
  • Staphylococcus aureus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Hydrogels
  • Polylysine
  • Monoamine Oxidase