Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping-Chung Kuo; Hsin-Yi Hung; Tsong-Long Hwang; Wen-Ke Du; Hsiang-Chih Ku; E-Jian Lee; Shih-Huang Tai; Fu-An Chen; Tian-Shung Wu

doi:10.1021/acs.jnatprod.7b00039

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

J Nat Prod. 2017 Apr 28;80(4):783-789. doi: 10.1021/acs.jnatprod.7b00039. Epub 2017 Apr 11.

Authors

Ping-Chung Kuo¹, Hsin-Yi Hung¹, Tsong-Long Hwang², Wen-Ke Du¹, Hsiang-Chih Ku², E-Jian Lee³, Shih-Huang Tai³, Fu-An Chen⁴, Tian-Shung Wu^{1

4}

Affiliations

¹ School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
² Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
³ Department of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.
⁴ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.

PMID: 28398735
DOI: 10.1021/acs.jnatprod.7b00039

Abstract

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification*
Anti-Inflammatory Agents / pharmacology*
Chalcones / chemistry
Chalcones / isolation & purification*
Chalcones / pharmacology*
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology*
Humans
Molecular Structure
Neutrophils / drug effects
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Elastase / antagonists & inhibitors
Resins, Plant / chemistry*
Superoxides / antagonists & inhibitors

Substances

Anti-Inflammatory Agents
Chalcones
Flavonoids
Resins, Plant
Superoxides
flavan-3-ol
Pancreatic Elastase