Persistence of a t(11;14)-positive clone in a patient with mantle cell lymphoma for 20 years

Yasuyuki Otsuka; Momoko Nishikori; Toshiyuki Kitano; Tomomi Oka; Takayuki Ishikawa; Hironori Haga; Akifumi Takaori-Kondo

doi:10.1002/ccr3.872

Persistence of a t(11;14)-positive clone in a patient with mantle cell lymphoma for 20 years

Clin Case Rep. 2017 Mar 2;5(4):477-481. doi: 10.1002/ccr3.872. eCollection 2017 Apr.

Authors

Yasuyuki Otsuka¹, Momoko Nishikori¹, Toshiyuki Kitano¹, Tomomi Oka¹, Takayuki Ishikawa², Hironori Haga³, Akifumi Takaori-Kondo¹

Affiliations

¹ Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
² Department of Hematology Kobe City Medical Center General Hospital Kobe Japan.
³ Department of Pathology Kyoto University Hospital Kyoto Japan.

Abstract

We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow up for such cases.

Keywords: Cyclin D1; Sox11; Splenectomy; mantle cell lymphoma; somatic hypermutation analysis.

Publication types

Case Reports