Abstract
The relationship between the polyoma virus tumor-specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli. The 2 proteins induced protective immunity against polyomavirus-induced tumors, but not against non-polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Formation
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Antigens, Neoplasm / immunology*
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Antigens, Polyomavirus Transforming / administration & dosage*
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Antigens, Polyomavirus Transforming / genetics
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Histocompatibility Antigens / immunology*
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Immunization*
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Mice
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Polyomavirus / immunology*
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Recombinant Proteins / administration & dosage
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Tumor Virus Infections / pathology
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Tumor Virus Infections / prevention & control*
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Viral Vaccines / administration & dosage*
Substances
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Antigens, Neoplasm
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Antigens, Polyomavirus Transforming
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Histocompatibility Antigens
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Recombinant Proteins
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Viral Vaccines
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tumor-associated transplantation antigen