Reference values for fasting serum resistin in healthy children and adolescents

Ulrik Lausten-Thomsen; Michael Christiansen; Paula Louise Hedley; Tenna Ruest Haarmark Nielsen; Cilius Esmann Fonvig; Oluf Pedersen; Torben Hansen; Jens-Christian Holm

doi:10.1016/j.cca.2017.04.002

Reference values for fasting serum resistin in healthy children and adolescents

Clin Chim Acta. 2017 Jun:469:161-165. doi: 10.1016/j.cca.2017.04.002. Epub 2017 Apr 6.

Authors

Ulrik Lausten-Thomsen¹, Michael Christiansen², Paula Louise Hedley³, Tenna Ruest Haarmark Nielsen⁴, Cilius Esmann Fonvig⁴, Oluf Pedersen⁵, Torben Hansen⁶, Jens-Christian Holm⁷

Affiliations

¹ The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. Electronic address: ulrik.lausten-thomsen@aphp.fr.
² Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
³ Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
⁴ The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁵ The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁶ The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁷ The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 28392328
DOI: 10.1016/j.cca.2017.04.002

Abstract

Background: Resistin is a hormone, mainly produced in macrophages and monocytes, believed to play an important role in the inflammatory response. It has been linked to several chronic diseases such as heart failure, inflammatory bowel disease, and insulin resistance. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum resistin concentrations.

Methods: A total of 1191 healthy, non-obese Danish schoolchildren (727 girls) aged 6-18years (median 11.9) were included. Fasting serum resistin concentrations were quantitated by Human Resistin ELISA Development kit, Duo Set (R&D Systems) following optimization.

Results: The overall median resistin concentration was 8.93ng/mL (interquartile range (IQR): 6.19-13.33, range 1.57-35.84) in boys and 10.42ng/mL (IQR: 7.25-15.68, range 1.60-44.00) in girls. The resistin concentration correlated to relative BMI in both boys (p=0.02) and girls (p<0.0001). Percentiles for each age group were calculated alongside smoothed percentile curves and an age correlated increase was demonstrated, albeit only in girls (p=0.02) and not in boys (p=0.35).

Conclusion: Fasting serum resistin concentrations differ between sexes in healthy children and adolescents and are correlated both with the sex- and age adjusted BMI, and in girls to age.

Keywords: Adipokines; Adolescents; Children; Humans; Reference values; Resistin.

MeSH terms

Adolescent
Blood Chemical Analysis / standards*
Child
Fasting / blood*
Female
Humans
Male
Puberty
Reference Values
Resistin / blood*
Sex Factors

Substances

Resistin