Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity

J Microbiol Methods. 2017 Jun:137:30-33. doi: 10.1016/j.mimet.2017.04.003. Epub 2017 Apr 5.

Abstract

A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.

Keywords: Carbapenems; Enterobacteriaceae; GES; IMP; Pseudomonas aeruginosa; VIM.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / analysis
  • Bacterial Proteins / metabolism*
  • Bacteriological Techniques / methods
  • Carbapenems / pharmacology
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology
  • Imipenem / pharmacology*
  • Meropenem
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / enzymology
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Thienamycins / pharmacokinetics*
  • beta-Lactamases / analysis
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Thienamycins
  • Imipenem
  • beta-Lactamases
  • carbapenemase
  • Meropenem