Roussoella solani causing keratomycosis, with an observed both sexual and asexual morphs

Kiyofumi Mochizuki; Takashi Nishida; Kazuhiro Murata; Kyoko Ishida; Atsuko Sunada; Seishi Asari; Kiyofumi Ohkusu; Kazuaki Tanaka

doi:10.1016/j.jiac.2017.03.005

Roussoella solani causing keratomycosis, with an observed both sexual and asexual morphs

J Infect Chemother. 2017 Sep;23(9):651-654. doi: 10.1016/j.jiac.2017.03.005. Epub 2017 Apr 25.

Authors

Kiyofumi Mochizuki¹, Takashi Nishida², Kazuhiro Murata², Kyoko Ishida³, Atsuko Sunada⁴, Seishi Asari⁴, Kiyofumi Ohkusu⁵, Kazuaki Tanaka⁶

Affiliations

¹ Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan. Electronic address: mochi-gif@umin.ac.jp.
² Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan.
³ Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan; Department of Ophthalmology, Toho University, Ohashi Medical Center, Tokyo, Japan.
⁴ Department of Medical Technology, Osaka University Hospital, Osaka, Japan.
⁵ Department of Microbiology, Tokyo Medical University, Graduate School of Medicine, Tokyo, Japan.
⁶ Faculty of Agriculture and Life Science, Hirosaki University, Aomori, Japan.

PMID: 28389166
DOI: 10.1016/j.jiac.2017.03.005

Abstract

We describe an 82-year-old male farmer who had diabetes mellitus with no history of ocular trauma by soil or plants and who developed a corneal infection due to a fungus. The organism was identified as Roussoella solani based on both the morphological characteristics and phylogenetic analysis using LSU and ITS nrDNA sequences. The sexual stage of R. solani is described and illustrated for the first time. The patient was treated successfully with a combination of topical and systemic voriconazole and micafungin. This case is the first report of keratomycosis caused by R. solani.

Keywords: Keratomycosis; Micafungin; Phylogeny; Roussoella solani; Taxonomy.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Antifungal Agents / therapeutic use
Ascomycota* / classification
Ascomycota* / isolation & purification
Ascomycota* / physiology
Echinocandins / therapeutic use
Eye Infections, Fungal / drug therapy
Eye Infections, Fungal / microbiology*
Farmers
Humans
Keratitis / drug therapy
Keratitis / microbiology*
Lipopeptides / therapeutic use
Male
Micafungin
Voriconazole / therapeutic use

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Voriconazole
Micafungin