Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy

Hongzhang Deng; Xuefei Zhao; Liandong Deng; Jianfeng Liu; Anjie Dong

doi:10.1016/j.jconrel.2017.04.002

Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy

J Control Release. 2017 Jun 10:255:142-153. doi: 10.1016/j.jconrel.2017.04.002. Epub 2017 Apr 4.

Authors

Hongzhang Deng¹, Xuefei Zhao¹, Liandong Deng², Jianfeng Liu³, Anjie Dong⁴

Affiliations

¹ Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
² Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
³ Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin 300192, China.
⁴ Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.. Electronic address: ajdong@tju.edu.cn.

PMID: 28385677
DOI: 10.1016/j.jconrel.2017.04.002

Abstract

The fact that the sensitivities of different tumor cells and different individuals to the actions of drug delivery system varied greatly, restricted the anticarcinogen to a desired therapeutic concentration. How to determine the destiny of drug delivery system in space and time is the main challenge to realize the precise anticancer therapy. In this paper, we reported a preparation of degradable nanoparticles (designated Pros-PDC) loaded DOX and IR780 with three functional domains: the charge-conversional feature with long circulation time and enhanced internalization, light-triggered reactive oxygen species (ROS) generation and subsequently ROS responsive anticancer drug release with a spatially and temporally precise fashion. The spatiotemporal drug release from the ROS activated Pros-PDC nanoparticles could be controlled by when and how long to perform laser irradiation. In the present work, multifunctions of DOX and IR780 loaded Pros-PDC nanoparticles, as a flexible, easily controllable drug release platform, had been certificated in vitro and in vivo.

Keywords: Acidity internalization; DOX; Precise anticancer therapy; Reactive oxygen species (ROS); Spatiotemporal drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacokinetics
Antineoplastic Agents / therapeutic use
Apoptosis / drug effects
Cell Line, Tumor
Doxorubicin / administration & dosage*
Doxorubicin / chemistry
Doxorubicin / pharmacokinetics
Doxorubicin / therapeutic use
Drug Liberation
Female
Indoles / administration & dosage*
Indoles / chemistry
Indoles / therapeutic use
Light
Mice, Inbred BALB C
Nanoparticles / administration & dosage*
Nanoparticles / chemistry
Nanoparticles / therapeutic use
Neoplasms / drug therapy
Neoplasms / metabolism*
Neoplasms / pathology
Reactive Oxygen Species / metabolism*
Tissue Distribution
Tumor Burden / drug effects

Substances

2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium
Antineoplastic Agents
Indoles
Reactive Oxygen Species
Doxorubicin