Research progress in advanced melanoma

Cancer Lett. 2017 Jul 1:397:120-126. doi: 10.1016/j.canlet.2017.03.037. Epub 2017 Apr 4.

Abstract

Melanoma is a malignant tumor with high rate of metastasis and poor prognosis. How melanoma develops and how to treat it will continue to be a hot topic. This review briefly summarizes the mechanism of melanoma development and the latest progress in its treatment.

Keywords: Genetic mutation; Melanoma; Treatment.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / adverse effects
  • Angiogenesis Inhibitors / therapeutic use*
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biomarkers, Tumor / genetics
  • Cancer Vaccines / therapeutic use
  • Disease Progression
  • Genetic Predisposition to Disease
  • Humans
  • Immunotherapy / adverse effects
  • Immunotherapy / methods*
  • Immunotherapy, Adoptive
  • Melanoma / blood supply
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Melanoma / immunology
  • Molecular Targeted Therapy
  • Mutation
  • Phenotype
  • Protein Kinase Inhibitors / adverse effects
  • Protein Kinase Inhibitors / therapeutic use*
  • Signal Transduction / drug effects
  • Skin Neoplasms / blood supply
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / immunology

Substances

  • Angiogenesis Inhibitors
  • Biomarkers, Tumor
  • Cancer Vaccines
  • Protein Kinase Inhibitors