Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile

Barbara Baro; Katrien Deroost; Tainá Raiol; Marcelo Brito; Anne C G Almeida; Armando de Menezes-Neto; Erick F G Figueiredo; Aline Alencar; Rodrigo Leitão; Fernando Val; Wuelton Monteiro; Anna Oliveira; Maria Del Pilar Armengol; Carmen Fernández-Becerra; Marcus V Lacerda; Hernando A Del Portillo

doi:10.1371/journal.pntd.0005365

Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile

PLoS Negl Trop Dis. 2017 Apr 6;11(4):e0005365. doi: 10.1371/journal.pntd.0005365. eCollection 2017 Apr.

Authors

Barbara Baro¹, Katrien Deroost¹, Tainá Raiol², Marcelo Brito^{1

3}, Anne C G Almeida^{1

3}, Armando de Menezes-Neto⁴, Erick F G Figueiredo¹, Aline Alencar^{1

3}, Rodrigo Leitão⁵, Fernando Val^{1

2}, Wuelton Monteiro^{1

2}, Anna Oliveira⁶, Maria Del Pilar Armengol⁶, Carmen Fernández-Becerra^{4

6}, Marcus V Lacerda^{1

2}, Hernando A Del Portillo^{4

6

7}

Affiliations

¹ Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.
² Fundação Oswaldo Cruz - Instituto Leônidas e Maria Deane (FIOCRUZ-Amazonas), Manaus, Amazonas, Brazil.
³ Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, Brazil.
⁴ ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
⁵ Fundação Hospitalar de Hematologia e Hematoterapia do Amazonas (HEMOAM), Manaus, Amazonas, Brazil.
⁶ Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain.
⁷ ICREA, Barcelona, Spain.

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow / parasitology*
Erythroid Cells / metabolism*
Humans
Malaria, Vivax / parasitology
Malaria, Vivax / pathology*
Male
MicroRNAs / genetics
MicroRNAs / metabolism*
Middle Aged
Plasmodium vivax / isolation & purification*
Transcriptome

Substances

MicroRNAs

Grants and funding

BB was supported by a FAPEAM Fellowship (Pró-Estado). KD was supported by a CAPES fellowship (Science Without Borders). AMN was supported by a CNPq fellowship. Work in the laboratory of ML (researcher from CNPq) is funded by FAPEAM, CNPq, and the Brazilian Ministry of Health. ISGlobal and IGTP are members of the CERCA Programme, Generalitat de Catalunya. Work in the laboratory of HAdP is supported by the Ministerio Español de Economía y Competitividad (SAF2016-80655-R) and by Fundación Ramón Areces. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.