Deciphering the effects of nelfinavir and lopinavir on epimastigote forms of Trypanosoma cruzi

Parasitol Int. 2017 Oct;66(5):529-536. doi: 10.1016/j.parint.2017.03.009. Epub 2017 Apr 2.
No abstract available

MeSH terms

  • Aspartic Acid Proteases / drug effects
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Flagella / drug effects
  • Flagella / ultrastructure
  • HIV Protease Inhibitors / pharmacology*
  • Lethal Dose 50
  • Lopinavir / pharmacology*
  • Microscopy, Electron, Scanning
  • Microscopy, Fluorescence
  • Microscopy, Interference
  • Mitochondria / drug effects
  • Mitochondria / enzymology
  • Mitochondria / physiology
  • Nelfinavir / pharmacology*
  • Oxidoreductases / drug effects
  • Oxidoreductases / metabolism
  • Permeability / drug effects
  • Proteasome Endopeptidase Complex / drug effects
  • Proteasome Endopeptidase Complex / metabolism
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma cruzi / drug effects*
  • Trypanosoma cruzi / enzymology
  • Trypanosoma cruzi / growth & development
  • Trypanosoma cruzi / physiology

Substances

  • HIV Protease Inhibitors
  • Trypanocidal Agents
  • Lopinavir
  • Oxidoreductases
  • Aspartic Acid Proteases
  • Proteasome Endopeptidase Complex
  • Nelfinavir