Characterization of the novel HLA-B*49:39 allele identified in a German leukaemia patient

HLA. 2017 Jul;90(1):43-45. doi: 10.1111/tan.13015. Epub 2017 Mar 30.

Abstract

HLA-B*49:39 allele is characterised by 1 amino acid substitution in the alpha 1 domain.

Keywords: HLA-B*49; hematopoietic stem cell transplantation; human leukocyte antigen-B; mismatched related donor; sequence-based typing.

Publication types

  • Case Reports

MeSH terms

  • Alleles*
  • Amino Acid Substitution
  • Base Sequence
  • Codon / chemistry
  • Exons*
  • Female
  • Gene Expression
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Haplotypes
  • Hematopoietic Stem Cell Transplantation*
  • Histocompatibility Testing
  • Humans
  • Leukemia / immunology
  • Leukemia / pathology
  • Leukemia / therapy*
  • Male
  • Nuclear Family
  • Pedigree
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Tissue Donors

Substances

  • Codon
  • HLA-B Antigens
  • HLA-B*49 antigen