Future Prospects of Biologic Therapies for Immunologic Diseases

Santhosh Kumar; Brant R Ward; Anne-Marie Irani

doi:10.1016/j.iac.2017.01.013

Future Prospects of Biologic Therapies for Immunologic Diseases

Immunol Allergy Clin North Am. 2017 May;37(2):431-448. doi: 10.1016/j.iac.2017.01.013.

Authors

Santhosh Kumar¹, Brant R Ward², Anne-Marie Irani³

Affiliations

¹ Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, CHoR Pavilion, 5th Floor, 1000 East Broad Street, Richmond, VA 23298-0225, USA. Electronic address: santhosh.kumar@vcuhealth.org.
² Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, CHoR Pavilion, 5th Floor, 1000 East Broad Street, Richmond, VA 23298-0225, USA; Division of Rheumatology, Allergy, and Immunology, Virginia Commonwealth University, McGuire Hall, Room 4-115A, 1112 East Clay Street, Richmond, VA 23298-0263, USA; Department of Microbiology and Immunology, Virginia Commonwealth University, 1101 East Marshall Street, P.O. Box 980678, Richmond, VA 23298, USA.
³ Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, CHoR Pavilion, 5th Floor, 1000 East Broad Street, Richmond, VA 23298-0225, USA.

PMID: 28366486
DOI: 10.1016/j.iac.2017.01.013

Abstract

This article presents an overview of future uses for biologic therapies in the treatment of immunologic and allergic conditions. Discussion is centered on the use of existing therapies outside of their current indication or on new therapies that are close to approval. This information may help familiarize practicing allergists and immunologists with therapies they may soon encounter in their practice as well as help identify conditions and treatments that will require further study in the near future.

Keywords: Asthma; Atopic dermatitis; Biologic; Churg-Strauss syndrome; Hemophagocytic lymphohistiocytosis; Immune dysregulation; Immunodeficiency; Mastocytosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Anti-Idiotypic / pharmacology
Antibodies, Anti-Idiotypic / therapeutic use
Antibodies, Monoclonal / pharmacology
Antibodies, Monoclonal / therapeutic use
Biological Products / pharmacology
Biological Products / therapeutic use
Biological Therapy* / methods
Biological Therapy* / trends
Cytokines / antagonists & inhibitors
Cytokines / metabolism
Desensitization, Immunologic
Disease Management
Humans
Immune System Diseases / diagnosis
Immune System Diseases / immunology
Immune System Diseases / metabolism
Immune System Diseases / therapy*
Molecular Targeted Therapy
Receptors, Cytokine / antagonists & inhibitors
Receptors, Cytokine / metabolism
Signal Transduction / drug effects

Substances

Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Biological Products
Cytokines
Receptors, Cytokine
anti-IgE antibodies